Optimized embryo transfer with EmbryoGlue®
EmbryoGlue® contains high concentration of hyaluronan (0.5 mg/mL) and low concentration of recombinant human albumin. It is uniquely developed to mimic the conditions in the female uterus in order to help embryos implant after transfer. Albumin, highly abundant in the female reproduction tract, serves as a source of energy and as a reservoir for the release of hormones, vitamins, and metals. Hyaluronan is present in the oviduct and uterine fluids, increases up to the time of implantation and decreases to near basal levels by the next day, indicating that it is important for implantation. It also indirectly promotes angiogenesis. By virtue of these properties, it improves apposition and attachment of embryos which are key steps in the process of implantation. It also increases viscosity, which promotes easy handling, facilitating ET process, and by virtue of apposition, it prevents expulsion of embryos from uterine cavity post transfer.